The Amulet of Helene is an artifact in Y: The Last Man.
History
On the day the plague strikes, the amulet was in Al Karak, Jordan in the possession of Dr. Frozan Hamad, whose family had kept it for generations.[1]
Possible significance
Moments before her death, Dr. Hamad says that her father told her "that a catastrophe comparable to the Trojan War would take place if [the Amulet was] ever removed from [Jordan]," though she does not believe this.[2]